The selective alpha2‐adrenergic receptor agonist dexmedetomidine (DEX) does not affect aortic pressure augmentation

D. Kurnik
Gbemiga G. Sofowora, Reading Hospital
M. Muszkat
P. A. Harris
A. J. Wood
C. M. Stein

Presented at the American Society for Clinical Pharmacology & Therapeutics Annual Meeting
March 2005
Orlando, FL


Despite a similar reduction in peripheral blood pressure (BP), antihypertensive drugs have variable effects on central blood pressure and its augmentation by the reflected pulse wave, a measure of arterial stiffness. Infusion of norepinephrine (NE) increases arterial stiffness. Centrally acting alpha2‐AR agonists decrease NE concentrations and blood pressure, but their effects on aortic pressure augmentation are not known.