Genotypic and Phenotypic Composition of Sickle Cell Disease in the Arab Population - A Systematic Review.
UNLABELLED: Sickle cell disease (SCD) is a genetic disease influenced by ethnicity and regional differences in its clinical course. Recent advances in the management of SCD with newer therapies are being introduced to the Western population. However, many of these treatments are yet to be used in the Arabic SCD population. Understanding the genetic variations of SCD regionally is essential to anticipate the utilization of new treatments. This systematic review's main objective is to pool the available data on the genetic composition of SCD in the Arabic population. Data for 44,034 patients was extracted from 184 studies (11 case reports, 8 case series, 56 retrospectives, 107 prospective observational studies, and 2 clinical trials) using PubMed, Scopus, and Google Scholar. Male (49%) and female (51%) patients were equally reported wherever gender was available (N=13105). Various SCD genotypes were reported in a total of 14,257 patients, including Hb SS (77%) Hb Sβ0 (9.9%), and Hb Sβ+ (7.2%), while the rest of the genotypes, including HbSC, HbSD, HbSE, HbSO Arab, Hb S/α-Thal, Hb Sβ0 + α-Thal, and HBS Oman were individually reported in
SYSTEMATIC REVIEW REGISTRATION: The protocol has been registered in the International Prospective Register of Systematic Reviews(PROSPERO):CRD42020218,666. https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=218666.
Pharmgenomics Pers Med
Ata, F., Rahhal, A., Malkawi, L., Iqbal, P., Khamees, I., Alhiyari, M., yousaf, z., Qasim, H., Alshurafa, A., Sardar, S., Javed, S., Fernyhough, L., & Yassin, M. (2023). Genotypic and Phenotypic Composition of Sickle Cell Disease in the Arab Population - A Systematic Review.. Pharmgenomics Pers Med, 16, 133-144. https://doi.org/https://doi.org/10.2147/pgpm.s391394