Abstract
Introduction: When confronted by two disease processes, physicians in all disciplines are faced with the question: Are they manifestations of a common etiology, or distinct entities co-occurring? Inherent in this dilemma is whether an aberration from normal is even a disease process at all. Tissue pathology plays a key role in resolving this conundrum. Although diagnoses can be challenging, there are various methodologies used in the field of pathology to ascertain whether two tumors are of the same or different origins.
Case Description: This case report reviews two patients with large ovarian neoplasms and surgical pathology revealing histopathological features of two distinct types of tumors, presenting the dilemma of “same or different?” A pathological review of one of the cases revealed that the tumor was composed of an uncommon mixture of Brenner tumor and mucinous cystadenoma. The second case’s initial pathology revealed a rare thecoma mixed with a more common tumor, serous cystadenoma. The combination of thecoma and serous cystadenoma has only been described in a few isolated case reports. Further pathologic evaluation revealed the second component was a fallopian tube remnant rather than a serous cystadenoma.
Discussion: Although this review is of academic interest and is in the context of benign disease, it is relevant and can be applied to malignant neoplasms as it is important for staging and treatment selection to know if two tumors are considered the same or different.
Recommended Citation
Ingram S, Raju P, Shaw W, Sowers S, Brenan-Rothschild K. Same Or Different? Resolution of Diagnostic Difficulty of Two Mixed Cell-Type Tumors in Ovarian Pathology.. Transformative Medicine. 2024; 3(3):82-88. doi: https://doi.org/10.54299/tmed/lifo5472.
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Investigative Techniques Commons, Obstetrics and Gynecology Commons, Oncology Commons, Pathology Commons, Surgical Procedures, Operative Commons, Urogenital System Commons