Effects of supersaturated oxygen therapy on infarct size and microvascular obstruction following myocardial infarction: A systematic review and meta-analysis.

Document Type

Article

Publication Date

3-2026

Abstract

BACKGROUND: Supersaturated oxygen (SSO₂) therapy is an emerging intervention to minimize myocardial damage and improve outcomes in patients with ST-segment elevation myocardial infarction (STEMI). This meta-analysis evaluated the efficacy of SSO₂ therapy to reduce infarct size and microvascular obstruction (MVO).

METHODS: PubMed, Embase, and Cochrane databases were systematically searched for studies comparing percutaneous coronary intervention (PCI) plus SSO

RESULTS: Six studies (n = 1660) were included with 548 patients (33%) receiving SSO₂ therapy. Pooled analysis showed that PCI plus SSO₂ significantly reduced infarct size (MD -4.31; 95% CI -6.70 to -1.92; P < .01) and MVO (SMD -0.72; 95% CI -1.11 to -0.34; P < .01) compared with PCI alone. MACE, all-cause mortality, re-infarction, and TVR were comparable between the groups.

CONCLUSION: SSO₂ therapy significantly reduced infarct size and MVO in patients undergoing PCI for STEMI.

Publication Title

American heart journal

Volume

293

First Page

107311

Last Page

107311

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