Light-activated molecular machines are fast-acting broad-spectrum antibacterials that target the membrane.

Authors

Ana L Santos
Dongdong Liu
Anna K Reed
Aaron M Wyderka
Alexis van Venrooy
John T Li
Victor D Li
Mikita Misiura
Olga Samoylova
Jacob L Beckham
Ciceron Ayala-Orozco
Anatoly B Kolomeisky
Lawrence B Alemany
Antonio Oliver
George P. Tegos, Office of Research, Reading Hospital, Tower Health, 420 S. Fifth Avenue, West Reading, PA 19611, USAFollow
James M Tour

Document Type

Article

Publication Date

6-3-2022

Abstract

The increasing occurrence of antibiotic-resistant bacteria and the dwindling antibiotic research and development pipeline have created a pressing global health crisis. Here, we report the discovery of a distinctive antibacterial therapy that uses visible (405 nanometers) light-activated synthetic molecular machines (MMs) to kill Gram-negative and Gram-positive bacteria, including methicillin-resistant

Publication Title

Sci Adv

Volume

8

Issue

22

First Page

2055

Last Page

2055

Recommended Citation

Santos, A., Liu, D., Reed, A., Wyderka, A., van Venrooy, A., Li, J., Li, V., Misiura, M., Samoylova, O., Beckham, J., Ayala-Orozco, C., Kolomeisky, A., Alemany, L., Oliver, A., Tegos, G. P., & Tour, J. (2022). Light-activated molecular machines are fast-acting broad-spectrum antibacterials that target the membrane.. Sci Adv, 8 (22), 2055-2055. https://doi.org/https://doi.org/10.1126%2Fsciadv.abm2055