Imaging, Histopathologic, and Treatment Nuances of Pulmonary Carcinosarcoma.
A 76-year-old female with coronary artery disease, chronic obstructive pulmonary disease, diabetes mellitus type II, and 40 pack-year smoking history presented with a four-day history of cough, productive of green-yellow sputum. Chest X-ray revealed opacification of the left upper lung field, and computed tomography (CT) of the chest showed a large cavitary lesion invading the T2-T3 vertebral bodies, extending into the epidural space, giving rise to mild cord compression. Biopsy of the lesion revealed a poorly differentiated neoplasm composed of distinct epithelial and mesenchymal components, consistent with carcinosarcoma. A metastatic workup was negative. Primary lung carcinosarcoma is a rare tumour that can demonstrate an especially aggressive clinical course; diagnosis is often nuanced by limited sampling at initial presentation, especially in a setting of advanced disease and debility that precludes consideration for upfront resection or more extensive, invasive sampling.
Case Rep Radiol
Gleason, T., Haas, M., & Le, B. (2017). Imaging, Histopathologic, and Treatment Nuances of Pulmonary Carcinosarcoma.. Case Rep Radiol, 2017, 8135957-8135957. https://doi.org/https://doi.org/10.1155%2F2017%2F8135957