A multi-center randomized trial of two different intravenous fluids during labor.

Authors

Lisa M Dapuzzo-Argiriou, Department of Obstetrics and Gynecology , Lehigh Valley Health Network , Allentown , PA
John C Smulian, Department of Obstetrics and Gynecology , Lehigh Valley Health Network , Allentown , PA
Meredith L Rochon, Department of Obstetrics and Gynecology , Lehigh Valley Health Network , Allentown , PA
Luisa Galdi, Department of Obstetrics and Gynecology , The Reading Hospital , Reading , PA
Jessika M Kissling, Department of Obstetrics and Gynecology , The Reading Hospital , Reading , PA
Peter F Schnatz, Department of Obstetrics and Gynecology , The Reading Hospital , Reading , PA
Angel Gonzalez Rios, Department of Obstetrics and Gynecology , St. Luke's University Hospital , Bethlehem , PA
James Airoldi, Department of Obstetrics and Gynecology , St. Luke's University Hospital , Bethlehem , PA
Mary Anne Carrillo, Department of Obstetrics and Gynecology , Pennsylvania State University College of Medicine , Hershey , PA
Jaimie Maines, Department of Obstetrics and Gynecology , Pennsylvania State University College of Medicine , Hershey , PA
Allen R Kunselman, Department of Public Health Sciences , Pennsylvania State University College of Medicine , Hershey , PA
John Repke, Department of Obstetrics and Gynecology , Pennsylvania State University College of Medicine , Hershey , PA
Richard S Legro, Department of Obstetrics and Gynecology , Pennsylvania State University College of Medicine , Hershey , PA

Document Type

Article

Publication Date

1-1-2016

Abstract

OBJECTIVE: To determine if the intrapartum use of a 5% glucose-containing intravenous solution decreases the chance of a cesarean delivery for women presenting in active labor.

METHODS: This was a multi-center, prospective, single (patient) blind, randomized study design implemented at four obstetric residency programs in Pennsylvania. Singleton, term, consenting women presenting in active spontaneous labor with a cervical dilation ofRinger's with or without 5% glucose (LR versus D5LR) as their maintenance intravenous fluid. The primary outcome was the cesarean birth rate. Secondary outcomes included labor characteristics, as well as maternal or neonatal complications.

RESULTS: There were 309 women analyzed. Demographic variables and admitting cervical dilation were similar among study groups. There was no significant difference in the cesarean delivery rate for the D5LR group (23/153 or 15.0%) versus the LR arm (18/156 or 11.5%), [RR (95% CI) of 1.32 (0.75, 2.35), p = 0.34]. There were no differences in augmentation rates or intrapartum complications.

CONCLUSIONS: The use of intravenous fluid containing 5% dextrose does not lower the chance of cesarean delivery for women admitted in active labor.

Publication Title

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

Volume

29

Issue

2

First Page

191

Last Page

196

Recommended Citation

Dapuzzo-Argiriou, L., Smulian, J., Rochon, M., Galdi, L., Kissling, J., Schnatz, P., Gonzalez Rios, A., Airoldi, J., Carrillo, M., Maines, J., Kunselman, A., Repke, J., & Legro, R. (2016). A multi-center randomized trial of two different intravenous fluids during labor.. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 29 (2), 191-196. https://doi.org/https://dx.doi.org/10.3109%2F14767058.2014.998190