TCT-14 Improved Survival but Higher Complication Rates in Women Undergoing TAVR: A Long-Term Sex-Based Outcome Analysis

Document Type

Abstract

Publication Date

10-28-2025

Abstract

Background: Sex-related differences in outcomes following transcatheter aortic valve replacement (TAVR) have been reported, but long-term comparative data remain limited. This study aims to compare long-term clinical outcomes between women and men undergoing TAVR. Methods: A total of 8,762 patients (4,139 women and 4,623 men) who underwent TAVR for severe symptomatic aortic stenosis were followed over a median of 3.8 years. The primary endpoint was all-cause mortality. Secondary endpoints included cardiovascular mortality, stroke, major bleeding, vascular complications, and rehospitalization. Adjusted hazard ratios (HR) and p-values were calculated using Cox proportional hazards models. Results: At long-term follow-up, women demonstrated a lower risk of all-cause mortality compared to men (HR 0.88, 95% CI 0.82–0.95, p = 0.002). Women had a significantly higher risk of major vascular complications (HR 1.34, 95% CI 1.19–1.51, p < 0.001) and major bleeding events (HR 1.21, 95% CI 1.10–1.33, p < 0.001). Stroke rates were similar between the sexes (p = 0.28). Women had significantly lower rates of cardiovascular mortality and rehospitalization. Conclusion: Despite a higher incidence of vascular and bleeding complications, women undergoing TAVR experienced significantly better long-term survival and lower cardiovascular mortality compared to men. These findings underscore the importance of sex-specific risk stratification and procedural planning in TAVR candidates. Categories: STRUCTURAL: Womens Health Issues: Structural

Publication Title

Journal of the American College of Cardiology

Volume

86

Issue

17 Supplement

First Page

B11

Last Page

B11

Comments

Transcatheter Cardiovascular Therapeutics held 2025-10-25 to 2025-10-28 in San Francisco, CA

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