Inflammatory Bowel Disease Following Allogeneic Hematopoietic Cell Transplant for Sickle Cell Disease.

Authors

Emily Rowland
Akshay Sharma
Samantha Paglinco, Department of Pediatric Gastroenterology, St. Christopher's Hospital for Children, Philadelphia, Pennsylvania, USAFollow
Ross M Maltz
Jeffrey E Deyo
Kiran Joglekar
John Brannon Alberty
Courtney Fitzhugh
Hemalatha G Rangarajan

Document Type

Article

Publication Date

1-2026

Abstract

Although graft-versus-host disease (GvHD) is an important cause of gastrointestinal (GI) complications after allogeneic hematopoietic stem cell transplantation (HCT), the non-specific symptoms make diagnosis challenging. We described three patients with sickle cell disease who developed inflammatory bowel disease (IBD) like manifestations 4-18 months post-HCT. All patients received peripheral blood stem cell grafts and sirolimus for GvHD prophylaxis. All had chronic diarrhea, and biopsies showed extensive colonic ulceration, non-necrotizing granulomas, with minimal histologic evidence of GvHD. Symptoms resolved promptly with IBD-directed therapy. Our report highlights the importance of considering alternative rare etiologies for GI complications such as IBD after HCT.

Publication Title

Pediatric blood & cancer

Volume

73

Issue

1

First Page

32121

Last Page

32121

Recommended Citation

Rowland, E., Sharma, A., Paglinco, S., Maltz, R., Deyo, J., Joglekar, K., Alberty, J., Fitzhugh, C., & Rangarajan, H. (2026). Inflammatory Bowel Disease Following Allogeneic Hematopoietic Cell Transplant for Sickle Cell Disease.. Pediatric blood & cancer, 73 (1), 32121-32121. https://doi.org/https://doi.org/10.1002/pbc.32121