Retrospective Analysis of Bleeding and Wound Complications After Preoperative Administration of Ketorolac in Acute Appendicitis

Authors

Kate Yurick MD, Department of Anesthesiology, Reading Hospital-Tower Health, West Reading, PA,Follow
Jahan Aslami MS, Drexel University College of MedicineFollow
John LeMoine BS, Drexel University College of MedicineFollow
Luke Rovenstine BS, Drexel University College of MedicineFollow
Tan Tran BS, Drexel University College of MedicineFollow
Traci Deaner MSN, RN, Department of Emergency Medicine, Reading Hospital-Tower Health, West Reading, PA,Follow
Thomas Wasser PhDFollow
Adam Sigal MD, Department of Emergency Medicine, Reading Hospital-Tower Health, West Reading, PA,Follow

Abstract

ABSTRACT:

Introduction:

Opioids are a mainstay of acute pain management and provide excellent analgesia for severe pain. However, their side effect profile and complication rates raise concerns regarding routine administration.

Methods:

This study is a retrospective cohort study of 1415 patients in a single tertiary care center comparing bleeding and operative complications in patients administered ketorolac prior to appendectomy.

Results:

There was no difference between the ketorolac and non-ketorolac groups regarding blood loss (0.7% vs 0.6%, p=0.572) and hemoperitoneum (0.4% vs 0.6%, p = 0.43) There was no difference between the groups regarding need for re-exploration (0.6% vs 0.6%, p=0.643).

Discussion:

The use of the cyclooxygenase inhibitor, ketorolac, did not result in an increase of surgical complications in patients undergoing appendectomy.

Keywords:

Peri-Operative, Analgesia, Opioid Use, Substance Use, Ketorolac, NSAID

Recommended Citation

Yurick K, Aslami J, LeMoine J, Rovenstine L, Tran T, Deaner T, Wasser T, Sigal A. Retrospective Analysis of Bleeding and Wound Complications After Preoperative Administration of Ketorolac in Acute Appendicitis. Transformative Medicine. 2025; 4(2):14-18. doi: https://doi.org/10.54299/tmed/pnfr7021.