The value of antimicrobial peptides in the age of resistance.
Document Type
Article
Publication Date
9-2020
Abstract
Accelerating growth and global expansion of antimicrobial resistance has deepened the need for discovery of novel antimicrobial agents. Antimicrobial peptides have clear advantages over conventional antibiotics which include slower emergence of resistance, broad-spectrum antibiofilm activity, and the ability to favourably modulate the host immune response. Broad bacterial susceptibility to antimicrobial peptides offers an additional tool to expand knowledge about the evolution of antimicrobial resistance. Structural and functional limitations, combined with a stricter regulatory environment, have hampered the clinical translation of antimicrobial peptides as potential therapeutic agents. Existing computational and experimental tools attempt to ease the preclinical and clinical development of antimicrobial peptides as novel therapeutics. This Review identifies the benefits, challenges, and opportunities of using antimicrobial peptides against multidrug-resistant pathogens, highlights advances in the deployment of novel promising antimicrobial peptides, and underlines the needs and priorities in designing focused development strategies taking into account the most advanced tools available.
Publication Title
The Lancet infectious diseases
Volume
20
Issue
9
First Page
e216
Last Page
e230
Recommended Citation
Magana, M., Pushpanathan, M., Santos, A., Leanse, L., Fernandez, M., Ioannidis, A., Giulianotti, M., Apidianakis, Y., Bradfute, S., Ferguson, A., Cherkasov, A., Seleem, M., Pinilla, C., de la Fuente-Nunez, C., Lazaridis, T., Dai, T., Houghten, R., Hancock, R., & Tegos, G. P. (2020). The value of antimicrobial peptides in the age of resistance.. The Lancet infectious diseases, 20 (9), e216-e230. https://doi.org/doi: 10.1016/S1473-3099(20)30327-3